Analysis Of The U.s. Auto Industry - 974 Words

ANALYSIS OF THE U.S. AUTO INDUSTRY OVERVIEW OF THE INDUSTRY United States Auto Industry’s presence in the International scene can be trace to 1896 when Henry Ford built the first car in America (Gale, 2003). He then revolutionized the industry with the invention of the assembly line. The assembly line allowed him to mass produce the cars making them more affordable to the consumers. Now local American manufacturers are General Motors (GM), Ford and Chrysler or FCA US. Currently brands like Acura, Aston Martin, Audi, Bentley, BMW, Bugatti, Ferrari, Fiat, Honda, Hyundai, Infiniti, Jaguar Land Rover, Kia, Lamborghini, Lexus, Lotus, Maserati, Mazda, McLaren, Mercedes-Benz, MINI, Mitsubishi, Nissan, Porsche, Rolls Royce, Smart, Subaru,†¦show more content†¦market share. (AIADA, 2015). Global competition in the industry According to the American International Automotive Dealers Association (AIADA) there are 16 major automakers competing in the U.S. A report by the Automotive News (2014) said that â€Å"the tight race for market share is ‘the new normal’ for the U.S. automotive market, and the battle for market share among the largest eight automakers in the U.S. is great now as the range between them continues to narrow†. It said General Motors and Ford Motor Co. have continued to occupy the top two positions over the last 14 years, but their lead has narrowed significantly as Toyota moved into the 3rd position ahead of Chrysler, now called FCA US. Ranking them by Market Share this is how the top ten stood by the end 2013: General Motors (GM) 17.9%, Ford 15.9%, Toyota 14.3%, FCA US 11.5%, and Honda 9.8%, Nissan 8.0%, Hyundai 4.6%, VW 3.7%, Kia 3.4% and Subaru 2.7%. (AIADA, 2014) International automakers’ share of U.S. vehicle sales continues to rise, now accounting for more than 59 percent of total industry sales. Last year’s sales increased by 29 percent, which reached 7.5 million vehicles. (Global Automakers, 2015). Moreover, as new platform hubs grow, foreign auto suppliers may build new plants in the U.S. to serve them. Nine out of 10 of the world’s largest automakers and 46 of the world’s top 50 global automotive suppliers have opened RD facilities in Michigan alone. New technology for powering

The Argument Of Entitlement And Desert - 1974 Words

In this paper I will defend John Arthur’s argument of entitlement and desert against Peter Singer’s theory of our duty to the global poor. We as privileged citizens, living in a prosperous country, do have some responsibility to help the tens of thousands of children under the age of 5 who die everyday from starvation and treatable disease. It seems natural that we as citizens of a first world country have a duty to help the global poor through charity. However that â€Å"duty† is vague and is under heavy moral debate. We as privileged citizens, living in a prosperous country, do have some responsibility to help the global poor. However, this rightful duty should not necessarily live up to the extreme and overwhelming expectations of Peter Singer. John Arthur’s argument of entitlement and desert is more realistic, logical, and more applicable to the world we live in today. Peter Singer’s central idea focuses around how grim death and suffering from lack of food, shelter and medical care really is. He further argues that if we can prevent something this unfortunate from happening, without sacrificing anything morally significant, we ought to do it. In other words, as privileged citizens, we ought to prevent all of the death and suffering that we can from lack of food, shelter and medical care from happening by giving our money and resources to charity (Chao, 2016, in-class discussion). In the terms of this argument, death and suffering from poverty are preventable with theShow MoreRelatedEssay on Discussing the Obligation to Help the Absolutely Poor828 Words   |  4 Pagesanswering this difficult question. To begin a comparative analysis of these theories, I will first go over the ideas that Singer represents in Rich and Poor, going on to analyze what Rachels and Nozick would say in response to Singers argument. In Rich and Poor, Singers basic principle is that when something is within ones power to prevent anything very bad from happening, without sacrificing anything of comparable moral significance, one ought to do so. He uses theRead MoreSummary Of Peter Singer s Argument1438 Words   |  6 PagesIn this paper I will discuss Peter Singer’s argument that it is our duty to aid to those in need, and John Arthur’s argument that we have competitive intuitions that have precedence over our duty to aid the needy. I will then argue that Arthur’s argument is more applicable to human kind as a species, simply due to the fact that human instinct is not capable of fulfilling Singer’s premise. Peter Singer argues that people who live in wealthier countries have an obligation to change their way of lifeRead MoreFamine, Affluence and Morality by Peter Singer1486 Words   |  6 PagesIn his own essay â€Å"Famine, Affluence and Morality†, Peter Singer puts forth some compelling arguments for affluent people to give what they have in excess, to the suffering people of the world. Before any criticism is made, here is the argument: - There are people suffering and dying from lack of food, shelter and medical care. - People suffering and dying from lack of food, shelter and medical care is bad. - If you have the power to prevent something bad from happening without sacrificing †¨anythingRead MoreArgument Against The Death Penalty1247 Words   |  5 Pagessociety that is not willing to demand a life of somebody who has taken somebody else’s life is simply immoral.† When considering the issue of capital punishment, many arguments are made in favor of proponents and abolitionists. There are utilitarian arguments, retributive arguments, and egalitarian arguments. Utilitarian arguments argue against the death penalty, for they look to punish criminals for the benefit and the â€Å"lesson learned† from the punishment. They believe that this is the most effectiveRead MoreThe Case For Death Penalty1252 Words   |  6 Pagessociety that is not willing to demand a life of somebody who has taken somebody else’s life is simply immoral.† When considering the issue of capital punishment, many arguments are made in favor of proponents and abolitionists. There are utilitarian arguments, retributive arguments, and egalitarian arguments. Utilitarian arguments argue against the death penalty, for they look to punish criminals for the benefit and the â€Å"lesson learned† from the punishment. They believe that this is the most effectiveRead More Illegal Immigration Essays1289 Words   |  6 Pagesother biased groups. If illegal immigration stays its present course the American tax-payer will continue to fund the well being of individuals who have broken federal rules and regulations and are being supported by law abiding citizens. This argument is not about individual rights to live and prosper. It is not about race or discrimination of any sort. It is only about the effects on health care that I am addressing. California has been plagued by budget deficiencies in recent years. LayoffsRead MorePrivatization And Deregulation Of Privatization1680 Words   |  7 Pagesgovernment institutions that the private sector seeks to privatize. A main argument for the privatization of this sector is that the public educational system has deteriorated. As noted by Friedman (1995), privatization is the only way to successfully improve the American educational system, as this â€Å"will provide a wide variety of learning opportunities and offer effective competition to public schools† (p. 1). In his argument for privatization, Friedman (1995) calls for a high-quality and universalRead More The Justification of Reverse Discrimination in Hiring Essay1580 Words   |  7 Pagesbecomes unnecessary. James Rachels bases his moral reasoning for reverse discrimination on what people deserve. Although he is conscious that reverse discrimination appears unfair to those directly affected, he proposes that fairness is dependent on desert. What an individual deserves lies on the effort and willpower for achievement (3. Rachels, CC2011, p 0201). Therefore, it is morally acceptable to execute preferential treatment towards a deserving individual if he or she put in more effort. Rachels’Read MoreThe Barbarian Nurseries Essay1186 Words   |  5 Pageshad an internal struggle with defining who she was, he is trying to understand the best route for his situation. Araceli not only goes through internal battles she also battles the justice system because of the mistakes of others. When a brutal argument between Scott and Maureen becomes heated and violent, the children are left in the care of Araceli. She struggles with what to do with the children. Her struggle with this begins when, â€Å"She stood with her arms folded and looked down the street, hopingRead MoreThe Filibuster1275 Words   |  6 Pagesleaving bills gridlocked in an oft-quarrelling Senate and slowing down imperative votes in favour of absolutely factional pick up (Roche, 1891). Dwindle Fenn, GOP advisor and previous Senate helper, called delays the oppression of the minority. Arguments for keeping, modifying, or ending the filibuster Keeping filibuster has some benefits especially to the minority group in the assembly and hence conservatives should kind off preserve filibuster. According to R-Neb, it encourages cool debating and

Implementing TQM in Small & Medium-Sized Organizations

Question: Describe about the Implementing TQM in small medium-sized organizations? Answer: Introduction Business organisations must consider various reasons that described Why it is essential to consider the quality issues for producing the quality products for their customers. Total Quality Management has been considered as a philosophy with several core values and principles that are centred over a continuous improvement of quality of the products along with services. A continuous product and services development is essential for every organisation for the very reason that customer demands are never stagnant and in order to meet the demands and needs organisation must implement continuous development in their products and services (Brown Et.al. 1994). The Principles of TQM (Total Quality Management) It is essential for business organisations to consider the never ending expectations of customers; moreover organisation cannot deny their customers demand because it is essential for organisations to have a clear grip over their group of customers. For implementing quality management system within the organisation, they must follow five fundamental principles, they are described below: Produce quality effort at once: This particular principle can help an organisation to encourage their workforce to start considering the factor of quality from the very first step of the production procedure. The organisation would also implement continual improvement measures for ensuring the competitive advantage. Focus must always be on the customers: Customers tend to grow a mentality that Anything that outweighs their expectations, are quality products. Thus the organisation must always consider this fact so that they can grow the tendency to produce and provide quality goods and services to their customers. Implement a competitive strategy for the improvement of products: Organisations must implement strategic approach for ensuring quality products are being produced. Strategic approaches will always help and organisation to meet their aims and provide best quality goods and services. Implement a continuous improvement: For producing quality goods it is essential for the organisation to evaluate their production on a continuous basis. An evaluation will help them to understand the areas that need continuous attention. This will help the organisation to gain popularity among various groups of customers (Chase, 1991). Support team work and mutual respect: Often a work station experience clashes within; the organisation must encourage the mutual respect and team work. For producing quality product a team effort is essential. Management structures that can lead to an effective quality organisation For producing quality goods and services it is essential for organisations to implement appropriate quality oriented strategies and policies so that teams responsible for producing goods and services concentrate over producing quality. The management structure will consists of appropriate tools and technologies that are dedicated towards producing goods complying with the standards of quality. It also is essential for organisations to evaluate their performance; a continuous evaluation will help them understand the requirements and needs that will help them to understand the requirements of production. The Application of TQM techniques in an organisation The TQM (Total Quality Management) has been categorized among various essential tools and techniques organisations can use ensuring a better quality of their products and services. Through TQM technologies organisations can focus on various aspects of production and concentrate upon producing quality product (Creech, 1994). Overall total quality control can be managed with the help of several essential tools and equipments. The TQM technology can be achieved by improving a better technology among various organizations. The team management can control TQM prospects by implementing appropriate technologies and tools that are so essential for organization to understand the basic requirements of the employees which can fulfil the production requirements. They can implement several mechanisms to support the entire team work and their manual aspects with the help of competitive strategy to overcome the organization problems. The Key factors necessary for implementation of a QA system The system of quality assurance or the (QA) is a system that ensures the quality of products that organisations produce. In a Quality Assurance system organisations process a continuous checking using a system of continuous monitoring of workers performance and through the gathering of solid evidence that will help the organisation to check if the quality is improving or not. Initially the organisation must develop a generalized idea or a framework that will help the workers to understand the policies for maintaining the quality of product but then the organisation must ensure that they implement the entire idea throughout the steps of production (Flood, 1993). Internal and External quality audit for control purpose There are third parties to ensure the standards of quality are maintained properly for ensuring products are being adhered properly. The auditing officials will inspect and ensure that the quality of product is maintained properly. The management can ensure quality prior to the production by ensuring effective staffs is employed. Factors affecting Costing There are various factors that affect the quality of products, they are mentioned below: Money Materials Management People Market Machines and Methods These are the factors that can put a major affect on the quality assurance of products. It can be observed that customer can understand the basic requirements of an organization within their expectation. Customer can manage for their money and materials to manage different types of people in the whole market by implementing different machines and new methods. These controls are coming from both internal and external quality management audit. Applications of quality control techniques There are various applications available for assuring quality control of products to be developed. These applications are equipped with various scales and standards that help organisations to ensure the quality of products are being maintained according to the standards of quality right from the very beginning stage of production. Organisations invest on various applications available for checking the quality of products and services; it is vital for organisations to implement the right kind of computer applications that will help them to ensure a high level of accuracy (Hodgetts, 1996). Quality control techniques to determine process capability A process is a distinctive combination of various materials, tools, appropriate method and the workforce for the purpose of producing desired output. There are various techniques available for controlling quality of production procedure. It also is essential to determine the capability of the process for ensuring quality factor of products. Software packages for collection and analysis For attaining the competitive advantage it is essential for organisations to produce goods that are of higher quality and must have the potential to attract customers from all round the globe. Organisations must control their quality for producing quality products so that they can attain the unique point where the cost will be lowest and revenue will as well be at the highest point. There are various software packages available for controlling quality of products like: MasterControl Quality suite Demonstration MasterControl suite Overview MasterControl Documents MasterControl Process MasterControl Training MasterControl QMS QEM Systems These are the software packages that organisations can use for ensuring the high level of quality of the products (Sashkin and Sashkin, 1993). In the given excel sheet it can be observed that the excel sheet is useful and essential to measure quality check control by managing their units. Different types of measurement tolls are analyzed in the given excel sheet. So the excel sheet is perfect or this particular report. References Brown, M., Hitchcock, D. and Willard, M. (1994). Why TQM fails and what to do about it. Burr Ridge, Ill.: Irwin Professional Pub. Chase, R. (1991). Implementing TQM. Kempston: IFS Publications. Creech, B. (1994). The five pillars of TQM. New York: Truman Talley Books/Dutton. Flood, R. (1993). Beyond TQM. Chichester: J. Wiley Sons. Hodgetts, R. (1996). Implementing TQM in small medium-sized organizations. New York: Amacom. Sashkin, M. and Sashkin, M. (1993). Putting total quality management to work. San Francisco: Berrett-Koehler. Stamatis, D. (1997). TQM engineering handbook. New York: Marcel Dekker. Willig, J. (1994). Environmental TQM. New York: McGraw-Hill.

Life Of Jesus Essays - Crucifixion Of Jesus, Prophets Of Islam

Life Of Jesus Great Men of God Throughout history our society has chose to recognize and remember certain individuals that have had a dramatic influence on our lives. Some of these individuals were of an evil nature, such as Hitler, but I would like to believe that the majority of the people we remember were the ones that had a positive influence on history, such as Jesus Christ and Martin Luther King Jr. I would like to reflect on the men who served a higher power that they called abba, father, or as we would recognize today, God. Jesus Christ is worshiped around the world as being the savior of all mankind. His birth was a miracle because he was born from a virgin. Taken from the Holy Bible, in Matthew 1:18-25, it states that Mary (the virgin) was to marry Joseph, but before they were married, she found out she was pregnant with the Son of God. Joseph was a man of good morals and was ashamed when he heard of Mary being with child. He planned to divorce her in private so she wouldnt be disgraced. An angel from God came to Joseph in a dream and told him, Joseph son of David, do not be afraid to take Mary home as your wife, because what is conceived in her is from the Holy Spirit. She will give birth to a son and you are to give him the name Jesus, because he will save his people from their sins. Joseph awakened and obeyed the angel of God, and He and Mary were married. But he had no union with her until she gave birth to a son. And he gave him the name Jesus. In a radio interview with the host Bob Edwards of the Morning Edition, and his guests Bruce Metzger, Professor, Princeton Theological Seminary, and Michael Coogan, Professor, Stonehill College, they discussed the history behind the story of Christmas. In their discussion they brought up the fact the Jesus was called Jesus of Nazareth but that the messiah was supposed to be from Bethlehem. They go on about the fact that if he was born in Bethlehem, then why is he called Jesus of Nazareth. Why Jesus would be from Nazareth and not Bethlehem, has led us to many questions and a lot of possible answers, such as, according to Michael Coogan, the idea that Jesus might have been from Nazareth all along. In my opinion, I see the gospels (Matthew, Mark, Luke and John) to be very repetitious. I also think though, that if something is said more than once, that the person who is saying it wants it to be remembered because it is important. Jesus life and death are described through out the gospels numerously. Meaning that his time on this earth was very important, and that he should be remembered. Throughout his life, Jesus performed many miracles. Examples of these miracles can be found in the Holy Bible in the gospels (Matthew, Mark, Luke and John). I would have to say that my favorite miracle performed by Jesus would have to be when Jesus fed the four thousand, in Mark 8:1-13. Jesus was surrounded by a large crowd and felt compassion for them. He wanted to provide food for everyone so they would be strong enough to travel back to their homes. They only had seven loaves of bread and a few fish, but after Jesus gave thanks and broke the bread, he told his disciples to pass out the food, and they did. When everyone was finished eating there was seven basketfuls of broken pieces left. Jesus Christ lived a short, yet extremely meaningful life. Starting with his miraculous birth, his life was full of awesome displays of God and ended with a gory triumph. His death was why he was sent to earth. In Matthew 27:22-26, it tells of when Jesus was being judged by Pilate. It states that Pilate, who was the governor at that time, said, What shall I do, then, with Jesus who is called Christ? Pilate asked. They all answered, Crucify him! Why? What crime has he committed? asked Pilate. But they shouted all the louder, Crucify him! Pilate knew

Romeo and Juliet Baz Luhrmanns film interpretation Essays

Romeo and Juliet Baz Luhrmanns film interpretation Essays Romeo and Juliet Baz Luhrmanns film interpretation Paper Romeo and Juliet Baz Luhrmanns film interpretation Paper The prologue creates family tension by portraying the violence and hate-filled from the very beginning. It introduces the feud to the audience and highlights how it will play a major role throughout the production. ‘From ancient grudge break to new mutiny’ this displays the confliction and rivalry between the two households. The prologue is used at the beginning of the play to inform the audience of the story line, and it is done to create pathos for the audience to help evoke emotion. It is presented as a sonnet; with three quatrains and a rhyming couplet at the end, this emphasizes the importance of the prologue. ‘From fort the fatal lion of these two foes, a pair of star-cross’d lover take their life’ this informs you of the key themes; death marked love and fate. Stars were often related to destiny therefore implying that Romeo and Juliet are destined to die. Baz Luhrmann further develops the family tension by presenting the prologue on a TV news broadcast; this heightens the tension as it shows the importance of the feud between the Montagues and Capulet’s. By using a black female reporter it shows the universal awareness, indicating the importance to be shown on national television. Using media also makes it look a lot more realistic and modernized. Luhrmann has used fire as a motif, to display the strong, hatred this is also used in act 1 scene 1. Luhrmann has projected the two household’s names on identical sky scrapers. They are in contrasting colours to emphasise. Furthermore the sky scrapers also convey their high status in society; they are both rich and powerful families. Finally helicopters have been used to evoke a sense of impression of a warzone. They are used to illustrate how the violence has subsided. Act 1 scene 5 creates further family tension, this is evident from â€Å"by his voice, this should be a Montague. Fetch me my rapier, boy. † This stresses the feud between the two household. â€Å"Rapier† is a long, thin sword commonly used in the 16th century for thrusting attacks. This therefore suggests that Tybalt is going to hurt Romeo, foreshadowing his death. Tybalt is presented as an antagonist throughout the production. He is outraged that a Montague is present at the party, however Capulet reprimands him. â€Å"He shall be endur’d† the word â€Å"shall† is a command, Tybalt isn’t given the option. This portrays Lord Capulet’s authority and hierarchy through the choice of lexis. Tension is evident between Lord Capulet and Tybalt through â€Å"I’ll make you quiet† this is an indirect threat, inferring that if he doesn’t back off he will become violent. Luhrmann further exemplifies the character through his choice of costumes. Tybalt is presented as the antagonist throughout the production. Luhrmann deliberately dresses him as a devil, because in most religions the devil is related to unnatural evil. The red costume can also be interpreted as connotation, to emphasise his anger. However, the glitter on the costume reduces the severity and intimidation of his character. Capulet is dressed as a royal emperor. He is predominantly in tyrian purple which would have only been affordable to the elites, so it is commonly associated with royalty and nobility. This further exemplifies his hierarchy and how powerful he his character is. Luhrmann interprets the scene adding extreme violence; Capulet forcefully slaps Tybalt cause inner family tension. This is then contrasted with In Act 3 scene 1, Mercutio further creates tension between the two houses by bellowing a curse on both the Capulet’s and the Montage’s . Their feud has killed him. â€Å"A plague on both your houses† The punctuation in this paragraph is very choppy. Changing the rhythm emphasizes and portrays his anger. Mercutio repeats the phrase three times during the scene to intensify the emotion and move the audience. This curse would have affected the audience them as their devout Christian belief made them very superstitious. This highlights one of the key themes; fate. Baz Luhrmann further develops this by using pathetic fallacy of thunder this is used to echo the mood of fear and add tension to the atmosphere. When Mercutio bellows this he is elevated above everyone else, making the curse more powerful and intense as if he is preaching. He uses a close up shot to illustrate the womb, Mercutio is wearing a white shirt this makes the womb look more horrific and serve. Luhrmann also inserts another clip into Act 3 scene 2 of Juliet in her bedroom; he uses a soliloquy to display her emotions and inner thoughts. The intense love displayed in the clip contrasts with the anger of Romeo before he kills Tybalt creates pathos for the audience. At beginning of act 3 scene 5, Juliet swears to her mother â€Å"I will not marry yet; and, when I do, I swear, It shall be Romeo† Shakespeare has used dramatic irony to add suspense and humour to the scene; as Juliet is already married to Romeo. This creates family tension due to the abandoned loyalty she has displayed towards her family. Juliet states she won’t look deeply into Paris’s eyes. No more deep will I endart mine eye†. In that era they believed that love entered through the eyes, she is therefore forbidding to love Paris. This contrasts with when she met Romeo for the first time. They gazed into each other’s eyes falling deeply in love. Baz Luhrmann further interpreted it as their eyes met looking into a fish tank. The fish tank represents the tranquillity, while all the chaos is happening around them. Juliet has been portrayed as a very gentle and calm character throughout the production, however in this scene she confronts her father and refuses to marry Paris. Capulet is outraged; this is evident from â€Å"my fingers itch† suggesting temptation for physical violence. â€Å"We have a curse in having her† suggesting having Juliet as a child was their misfortune; this emphasises his shame and hatred. The word â€Å"curse† would have had a strong effect on the audience as they were extremely superstitious. Capulet is so enraged he threatens to disown her if she refuses to marry â€Å"Or never after look me in the face†. This was like a death penalty to women as they were unable to earn money due in the patriarchal society they lived in. An Elizabethan audience would have found this moving. It also highlights one of the key themes of the production; honour! Baz Luhrmann further develops family tension in Act 3 scene 5 through the stage directions of the mother. Lady Capulet’s fear of talking to Juliet without the Nurse present establishes her as an ineffectual mother. Tension is created due to the lack of mother and daughter relationship which is apparent throughout the production. He also includes brutal attack and violence against Juliet this highlights the inner family tension. this by using different angles with the camera. He uses a close up shot of Capulet, concentrating on his face. This highlights the expression of anger. Capulet’s strong tone of voice portrays his anger and emotion. He uses fast music to create mood and atmosphere. Baz Luhrmann has successfully modernised Shakespeare’s Romeo and Juliet for a contemporary audience. Luhrmann uses visual techniques of lighting, colour and camera angles to convey atmosphere of tension and related emotions.

Independent Executive Agencies of US Government

Independent Executive Agencies of US Government Independent executive agencies of the U.S. federal government are those that, while technically part of the executive branch, are self-governed and not directly controlled by the President. Among other duties, these independent agencies and commissions are responsible for the vitally important federal rulemaking process. In general, independent agencies are tasked with administering laws and federal regulations that apply to specific areas such as the environment, social security, homeland security, education, and veteran affairs. Responsibilities and the Chain of Command Expected to be experts in the areas they manage, most independent agencies are headed by a presidentially-appointed board or commission, while a few, such as the EPA, are headed by a single presidentially-appointed administrator or director. Falling within the executive branch of government, independent agencies are overseen by Congress, but operate with more autonomy than federal agencies headed by Cabinet members such as the Departments of State or Treasury which must report directly to the president. While independent agencies do not answer directly to the president, their department heads are appointed by the president, with the approval of the Senate. However, unlike the department heads of executive branch agencies, such as those making up the president’s Cabinet, who can be removed simply because of their political party affiliation, heads of independent executive agencies may be removed only in cases of poor performance or unethical activities. In addition, the organizational structure independent executive agencies allows them to create their own rules and performance standards, deal with conflicts, and discipline employees who violate agency regulations.  Ã‚   Creation of Independent Executive Agencies For the first 73 years of its history, the young American republic operated with only four government agencies: the Departments of War, State, Navy, and Treasury, and the Office of the Attorney General. As more territories gained statehood and the nation’s population grew, the people’s demand for more services and protections from the government grew as well. Facing these new government responsibilities, Congress created the Department of the Interior in 1849, the Department of Justice in 1870, and the Post Office Department (now the U.S. Postal Service) in 1872. The end of the Civil War in 1865 ushered in a tremendous growth of business and industry in America. Seeing a need to ensure fair and ethical competition and control fees, Congress began creating independent economic regulatory agencies or â€Å"commissions.† The first of these, the Interstate Commerce Commission (ICC), was created in 1887 to regulate the railroad (and later the trucking) industries to ensure fair rates and competition and to prevent rate discrimination. Farmers and merchants had complained to lawmakers that railroads were charging them exorbitant fees to carry their goods to market.   Congress eventually abolished the ICC in 1995, dividing its powers and duties among new, more tightly defined commissions. Modern independent regulatory commissions patterned after the ICC include the Federal Trade Commission, the Federal Communications Commission, and the U.S. Securities and Exchange Commission. Independent Executive Agencies Today Today, independent executive regulatory agencies and commissions are responsible for creating the many federal regulations intended to enforce the laws passed by Congress. For example, the Federal Trade Commission creates regulations to implement and enforce a wide variety of consumer protection laws such as the Telemarketing and Consumer Fraud and Abuse Prevention Act, the Truth in Lending Act, and the Childrens Online Privacy Protection Act. Most independent regulatory agencies have the authority to conduct investigations, impose fines or other civil penalties, and otherwise, limit the activities of parties proven to be in violation of federal regulations. For example, the Federal Trade Commission often halts deceptive advertising practices and forces business to issue refunds to consumers. Their general independence from politically motivated interference or influence gives the regulatory agencies the flexibility to respond rapidly to complex cases of abusive activities. What Sets Independent Executive Agencies Apart? Independent agencies differ from the other executive branch departments and agencies mainly in their makeup, function, and the degree to which they are controlled by the president. Unlike most executive branch agencies which are overseen by a single secretary, administrator, or director appointed by the president, independent agencies are usually controlled by a commission or board made up of from five to seven people who share power equally. While the commission or board members are appointed by the president with the approval of the Senate, they typically serve staggered terms, often lasting longer than a four-year presidential term. As a result, the same president will rarely get to appoint all of the commissioners of any given independent agency. In addition, federal statutes limit the president’s authority to remove commissioners to cases of incapacity, neglect of duty, malfeasance, or â€Å"other good cause.† Commissioners of independent agencies cannot be removed based simply on their political party affiliation. In fact, most independent agencies are required by law to have a  bipartisan membership of their commissions or boards, thus preventing the president from filling vacancies exclusively with members of their own political party. In contrast, the president has the power remove the individual secretaries, administrators, or directors of the regular executive agencies at will and without showing cause. Under Article 1, Section 6, Clause 2 of the Constitution, members of Congress cannot serve on the commissions or boards of independent agencies during their terms in office. Agency Examples A few examples of hundreds of independent executive federal agencies not already mentioned include: Central Intelligence Agency (CIA): The CIA provides intelligence regarding potential threats to national security to the president and senior U.S. policymakers.Consumer Product Safety Commission (CPSC): Protects the public from unreasonable risks of injury or death from a vast array of consumer products.Defense Nuclear Facilities Safety Board: Oversees the nuclear weapons complex operated by the U.S. Department of Energy.Federal Communications Commission (FCC): Regulates interstate and international communications by radio, television, wire, satellite and cable.Federal Election Commission (FEC): Administers and enforces the campaign finance laws in the United States.Federal Emergency Management Agency (FEMA): Administers the national flood insurance and disaster relief programs. Works with first responders to prepare for, protect against, respond to, recover from, and mitigate all forms of hazards.Federal Reserve Board of Governors: Functions as the central bank of the United States. The Federal Reserve System (the â€Å"FED†) oversees the nation’s monetary and credit policy and works ensure the safety and stability of the nation’s banking and financial system.

Select a topic you would like to write ( writing about drama) Essay

Select a topic you would like to write ( writing about drama) - Essay Example American women in the 19th century were deterred from lustrous careers and they were denied self independence by the men. Their main sphere of operation in the society was restricted to the kitchen and the bedroom. Women did not have the right to vote or sit as members of the jury. Their opinions were considered of less importance in making essential decisions in the American education system, politics, economy, legislation and many others. Men in the US, in the 19th century, dominated all aspects of life in the American society except the nurturing of children and families; an activity that was allocated to women. In the play â€Å"Trifles† by Susan Glaspell, women are considered less educated, less equipped, less qualified and inferior to compete in the male dominated society. The men claimed the society advanced due to their intellectual property, strength, skills and ability to develop emotional intelligence in solving societal problems. George Henderson is a young but professional county attorney (Glaspell 455). He is called upon by local residents to investigate a murder case of Mr. John Wright, who was strangled by a rope in the wee hours of the night in his sleep. The county attorney has great respect for the law although he is quick to dismiss the female characters’ vested interest in non-essential details concerning domestic work. He also disparages the suspect, Mrs. Wright, for what he observes as lack of proper and normal house cleaning abilities allocated to women. Henry Peters, a middle aged man, is the area sheriff and Mrs. Peter’s Husband (Glaspell 455). He is interested in the murder case because it is his duty as a law enforcer to protect and serve the locals. Like the county attorney, he teases the female characters on their topic of conversation, which is the suspect’s quilt. He uses laughs light-heartedly at the women’s less

Gilamesh and Eygptian poetry Coursework Example | Topics and Well Written Essays - 500 words

Gilamesh and Eygptian poetry - Coursework Example These attributes soften Gilgamesh and they become fast friends. Gilgamesh lives to conquer, preferably in the limelight so everyone can see his strength. As he matures throughout the story, this tendency fades as he becomes aware of the mortality of all living things. The three themes weave together to add flow to the epic poem. 3. Enkidu is the foil for Gilgamesh because he does not esteem worldly riches or favor. He does appreciate the advantages of civilization, having once been a wild man, but he does not seek for self-aggrandizement as does Gilgamesh. Where Gilgamesh is brazen, Enkidu is cautious and humble. The ultimate foil provided by Enkidu is his death in opposition to Gilgamesh’s seemingly indestructible nature. 4. Gilgamesh encounters stone scorpions and a ferryman on his quest to obtain immortality. He is also challenged to stay awake for seven days and six nights. To varying degrees, Gilgamesh fails to overcome each of these obstacles. 5. Gilgamesh’s destruction of the ferryman’s boat is typical behavior for him. He is used to just shouting and bullying to get his way. In the process, he destroys the very thing he needs to accomplish his quest. He seems like the type of character that is given to taking action before he thinks through all of the consequences of the action. 6. The gods took council against the humans they destroyed because their service no longer pleased them. Humans were created to serve the gods and do their will, but the gods were not appeased. They regretted their council after they destroyed all the living things of the earth except Utnapishtim, his wife and all the animals, gold, silver etc. Luckily one of the gods told the walls of Utnapistim’s house (not actually the human) that he should build a huge boat to hold all of these things because a flood was coming. 7. Gilgamesh fails to stay awake in paradise for six days and seven nights. He also fails to eat the magical plant that he retrieved

Indus Motors Political Effect on Pakistan Essay Example for Free

Indus Motors Political Effect on Pakistan Essay Political Effects The government today has a key influence in the organizations, who are working in the country in order to gain maximum profit out of minimum cost, because of that government make new policies against the auto industries in Pakistan Toyota Indus motors is the factor affecting the auto industry in Pakistan .The Indus motors company’s plant is the only manufacturing site in the world where both Toyota and Daihatsu brands are being manufactured. Production of Toyota corolla vehicles in august plunged to 2,627 units from 2,914 units in July 2012. however, sales in august improved to 2,800 from 2,464 units in July 2012. There are some political points which are affecting the company.  ·Import duty  ·Banned CNG kits  ·Law and order Import duty: Every overseas Pakistani, subject to Fulfillment of eligible conditions as laid down in the import trade and procedure order 2000 can import a vehicle from abroad. The import policy often revised from time to time usually from after every financial year. The government has announced the import duty on auto industries with the rate of 100% tax. Banned CNG kits : ECC (economic coordination comity) approved the ban on import of CNG cylinders and conversation kits in the wake of current gas shortage in the country. The installation of new CNG kits in vehicles will also be banned, which affects the company’s sale figures resulting in decreasing of auto sales in Pakistan for certain time because of the Pakistani consumer’s interest in CNG, after some time of banishment of the CNG consumers started to convert their perception against CNG and started to purchase the new vehicles without CNG kit in it.

Comparing On the Road and Easy Rider :: Comparison Compare Contrast Essays

Parallels in On the Road  and Easy Rider  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚        Ã‚  Ã‚   Released more than a decade apart, Kerouac's On the Road and Dennis Hopper's Easy Rider are replete with parallels. Both depict characters whose beliefs are not quite uniform with those of society; in both cases these characters set out in search of "kicks" but become part of something larger along the way. More importantly, these two texts each comment insightfully on the culture of their respective times. But all these similarities become superficial in the face of the inherent differences between the two. In pre-Beat Generation America, anyone who looked could find a whole society of people who, for the most part, were afraid to do the things they dreamed, unable to break from conformity. Kerouac saw this all around him, and with On the Road, he responds. He presents a tale of those who flee conformity successfully and without any significant negative consequences. Clearly, his audience consists of members of society who remain content with conventional societal norms, who are too squeamish to do what they want. To them he argues that they ought to assert their personal identity rather than be bound by an imposed social one, that they ought to follow their own desires rather than succumb to society's. This argument comes in multiple forms; criticisms by Dean are such a form. At one point he cries: "the moment it comes time to act, this paralysis, scared, hysterical, nothing frightens em more than what they want" (Kerouac 215). He also complains: "offer them what they secretly want and they of course immediately become panic- stricken" (Kerouac 209). These statements are part of Kerouac's argument in their critique of society's fearful attitude toward achieving desires. Sal reiterates the argument to disregard social identity when he accuses a girl he meets of an "emptiness. . .that reached back generations and generations in her blood from not having done what was crying to be done. . .'What do you want out of life?' I wanted to take her and wring it out of her" (Kerouac 243). But Kerouac's strongest argument of all for individual freedom seems to come from example. In On the Road, Sal and Dean live an amazing adventure together. Sure, they get pulled over a few times, but no real harm comes to them from any of their wild escapades. Apparently they are untouchable.

Attack on Pearl Harbor Essay

Attack on Pearl Harbor was a surprise military strike conducted by the Imperial Japanese Navy against the United States naval base at Pearl Harbor, Hawaii, on the morning of December 7, 1941. The sneak attack sparked outrage in the American populace, news media, government and the world. On December 8, President Franklin D. Roosevelt addressed the American Congress, and the nation, to detail the attack. The attack took place before any formal declaration of war was made by Japan, but this was not Admiral Yamamoto’s intention which he thought that the attack should not commence until thirty minutes after Japan had informed the United States that peace negotiations were at an end. It was intended to neutralize the U.S. Pacific Fleet, and hence protect Japan’s advance into Malaya and the Dutch East Indies, where it sought access to natural resources such as oil and rubber. It was also an action in order to keep the U.S. Pacific Fleet from interfering with military actions the Empire of Japan was planning in Southeast Asia against overseas territories of the United Kingdom, the Netherlands, and the United States. The base was attacked by Japanese fighters, bombers and torpedo planes in two waves, launched from six aircraft carriers. All eight U.S. Navy battleships were damaged, with four being sunk; which two were raised, and with four repaired, six battleships returned to service later in the war. There were 188 U.S. aircraft that was destroyed; 2,402 Americans were killed and 1,282 wounded, and Japanese losses were light: 29 aircraft and five midget submarines lost, and 65 servicemen killed or wounded. The attack came as a profound shock to the American people and led directly to the American entry into World War II in both the Pacific and European theaters and the next day United States declared war on Japan. The attack had several major aims which were it intended to destroy important American fleet units, thereby preventing the Pacific Fleet from interfering with Japanese conquest of the Dutch East Indies and Malaya, it was hoped to buy time for Japan to consolidate its position and increase its naval strength before shipbuilding authorized by the 1940 Vinson-Walsh Act erased any chance of victory, and it was meant to deliver a severe blow to American morale, one which would discourage Americans from committing to a war extending into the western Pacific Ocean and Dutch East Indies. To maximize the effect on morale, battleships were chosen as the main targets, since they were the prestige ships of any navy at the time and the main intention was to enable Japan to conquer Southeast Asia without interference. On November 26, 1941, a Japanese task force, of six aircraft carriers departed northern Japan route to a position northwest of Hawaii, intending to launch its aircraft to attack Pearl Harbor. 408 aircraft were intended to be used: 360 for the two attack waves, 48 on defensive combat air patrol including nine fighters from the first wave. Before the attack commenced, two reconnaissance aircraft launched from cruisers were sent to scout over Oahu and report on enemy fleet composition and location. Another four scout planes patrolled the area between the Japanese carrier force and Niihau, so they could prevent the task force from being caught by a surprise counterattack. At 6:00 a.m. on 7 December, the six Japanese carriers launched a first wave of 181 planes composed of torpedo bombers, dive bombers, horizontal bombers and fighters. The first wave approached land, and one at least radioed a somewhat incoherent warning and other signs were ships off the harbor entrance were still being processed or awaiting confirmation when the attacking planes began bombing and strafing. The second wave consisted of 171 planes and 90 minutes after it began, the attack was over 2,386 Americans died and 1,139 wounded there were 18 ships that sunk or run aground, including five battleships. Several Japanese junior officers urged Nagumo to carry out a third strike in order to destroy as much of Pearl Harbor’s fuel and torpedo storage, maintenance, and dry dock facilities as possible; and the captains of the other five carriers in the formation reported they were willing and ready to carry out a third strike.

Wage Gap Between Genders

Earnings often signify how in dividends are valued socially and economically, therefore earning ratios between men and omen have been essential for social movements. The remaining is often wage discriminate ion since it is the difference in earnings between identical males and females. Women with equal 1 credentials should be paid equal as men Pay Equity & Discrimination Women should be paid equally as men because gender makes no difference I n what a person can do on the job.The resulting â€Å"urban legends† of gender difference can affect men and women at work and at home, as parents and as partners. When it co mess to personal relationships, bestselling books and popular magazines often claim t at women and men don't get along because they communicate too differently. A lot of people believe that just being female they can not do the same as males. The fact that people belie eve females to be physically and mentally shows discrimination in genders. Women are been g put dow n because of their gender but can be physically and mentally better than men.As stated in Human Psychology 101 most discrimination is due to past prejudice. Whooped and ‘Pay Equity & Discrimination Institute for women's policy 201 1. 9 DCE. 20 14 others were regarded as women's most significant professions. Since e early times women have been uniquely viewed as a creative source of human life. Women should be paid equally as men because historically the inequality has proven to be pure discrimination.Discrimination between genders is deeply rooted in our modern society. The gender pay gap affects all Women, but for Women Of cool r the wage gap is worse. Asian American women's salaries show the smallest gender pay gap, at 90 percent of white men's earnings. Hispanic women's salaries show the largest gap, at 5 4 percent of white men's earnings. White men are used as a benchmark because they make e up the largest demographic group in the labor force. Let is unlawful to harass a person because of that person's sex.Harassment can include â€Å"sexual harassment† or unwelcome sex al advances, requests for sexual favors, and other verbal or physical harassment of a sex al nature. Harassment does not have to be of a sexual nature, however, and can include offensive remarks about a person's goalmouths the law doesn't prohibit simple teasing g, offhand comments, or isolated incidents that are not very serious, harassment is illegal I when it is so request or severe that It creates a hostile or offensive work environment or when it results in an adverse employment decision..Most discrimination is caused due to either peer pressure to curry favor with their friends around them, or because they have a total lack k of selectors and selfsame, and they can't feel good about who they are unless they are p outing down someone else, or making another person feel badly. In the past most believed that the male gender was the superior gender and put women down to keep it that way. W omen were first thought to only be made to carry children and do household chores.Before it as prohibited for women to have professions except for teaching and writing. Some feared t hat the female gender would take over. It is unlawful to harass a person because of that person's sex. Discrimination between genders is nothing new; it all goes back to before cool nail times. In the 1 9th century the medical profession was an example of a change d attitude. Beginning in the 19th century education was required but, women were bare d from attending colleges for any profession other than teaching.This usually proven Ted women that married and bore child's at young ages to begin any professional career they c SSE. Around this time discrimination rose. For example in 1846 the American Medical Sass conation barred women from being members. It wasn't until 1915 that the American Medical a association began to allow female admittance-Since the signing Of the equal pay act Of 1 9 63, it is now illegal to pay men and women substantially different wages for equal work (N WAC, 2013).Pay difference between men and women remains a hot topic that keeps resume facing over the years and reasons behind the gap are highly debated. Gendered violence (GOB) is violence that is directed against a person on t he basis of gender. It constitutes a breach of the fundamental right to life, liberty, security, dignity, equality between women and men, nondiscrimination and physical an d mental integrity. Gendered violence and violence against women are often used indistinguishable as most gendered violence is inflicted by men on women and girls.Gendered violence includes: domestic violence, sexual harassment, rape, sexual violence during conflict an d harmful customary or traditional practices such as female genital mutilation, f arced marriages and honor crimes trafficking in women, forced prostitution and violations of human rights in AR De conflict (in particular murder, sys tematic rape, sexual slavery and forced pregnancy) ; forced sterilization, forced abortion, coercive use of contraceptives, female infanticide and prenatal sex selection. Domestic violence remains one of the most widespread forms of genders violence.Battering, often referred to as domestic violence happens to women of every age, race, class, and nationality. Battering takes many forms and includes a RA Eng of threatening and harmful behavior. It may take the form of verbal and emotion anal abuse, with the direct or implied threat of violence. Gender equality is a human right. Gender Equality is not only a fundamental human right, but a necessary foundation for the creation of sustainable and p useful societies. Women are entitled to live with dignity and with freedom from want and from fear.Women are treated in many other aspects Of life as equals so why not be paid equally also. Gender equality is at the very heart of human rights and United Nations values. A fundamental principle of the United Nations Charter adopted by woo RL leaders in 1945 is â€Å"equal rights for men and women†, and protecting and promoting woo men's human rights is the responsibility of all States. Empowered women contribute o the health and productivity of whole families and communities, and they improve pros sects for the next generation.All women and girls have equal access to quality education, employment, housing, and health, irrespective of race, class, income, immigrant Zion Status or involvement with the criminal justice system. For more than 30 years, LINEN A has advocated for women and girls, promoting legal and policy reforms and gene resistive data collection, and supporting initiatives that improve women's health and e expand their choices in life. Protecting and promoting her reproductive rights is essential t ensuring her freedom to participate more fully and equally in society.The UCLA has alls o been working to secure gender rights and ensure all women's are abl e to lead lives of dignity free from violence and discrimination. They have been making sure that educe action privileges are equal between genders. They keep all job opportunities the as me. All opportunities are being kept equal yet women still haven't been given an ex. al and fair amount of pay. Women have been in the workforce for generations. They strives to be equal to men and gain the same rights as them.

What to Expect During a Grad School Interview

What to Expect During a Grad School Interview Knowing what to expect during a grad school interview is key to effectively answering the questions youre asked. Graduate school acceptance rates in 2017 were approximately 22% for doctoral programs and 50% for masters degree programs, according to the Council of Graduate Schools. The interview is your opportunity to show the admissions committee the person you are beyond test scores, grades, and portfolios. Describe Yourself Interviewers often begin by asking applicants about themselves to put them at ease and for the interviewers to get a sense of who the applicants are as individuals. Admissions officers and faculty want to know what motivates you as a student and how your personal interests relate to your goals as a graduate student. Some common questions are: Tell me about yourself.What are your strengths and weaknesses?What do you believe your greatest challenge will be if you are accepted into this program?How would your professors describe you?Describe your greatest accomplishment.Why should we choose you over another candidate?Are you motivated? Explain and provide examples.What would you change about yourself and why?If you could have dinner with anyone, living or dead, who would it be? Why?What do you do in your spare time?What volunteer experiences do you have?What contribution have you made to your department or school?What was the last movie that you saw?What was the last book that you read? Describe Your Professional Goals Personal questions often segue into ones about your professional plans and interests. These arent limited to the graduate program to which youre applying. Be prepared to talk about what you may do if you arent admitted to grad school as well as what you plan to do upon graduation. Interviewers ask these questions to get a sense of how much thought you have put into your plans. If youre not accepted into graduate school, what are your plans?Why did you choose this career?How will you be able to make a contribution to this field?What are your career goals? How will this program help you achieve your goals?How do you intend to finance your education?What do you plan to specialize in? Describe Your Academic Experiences Academic institutions want to make sure theyre bringing in students who will become positive members of the departmental community and will develop healthy faculty relationships. Your experience as an undergraduate may indicate how good a fit the program is for you. In college, what courses did you enjoy the most? The least? Why?Describe any research project youve worked on. What was the purpose of the project, and what was your role in the project?In what ways have your previous experiences prepared you for graduate study in our program?Tell me about your experience in this field. What was challenging? What was your contribution?What skills do you bring to the program?How will you contribute to your mentors research?Why did you choose to apply to our program?What do you know about our program, and how does it align with your goals?What other schools are you considering? Why?If you could change one thing about your undergraduate college, what would it be?Tell me about a professor who you dont like. Why? Describe Your Problem Solving and Leadership Skills Grad school can be a stressful time for even the most successful students. There will be times when you will be pushed to your intellectual limits and must find your own way forward. Interview questions about your leadership skills and problem-solving abilities are a way for admissions advisers and faculty to understand how you function by yourself and in a group during demanding times. Explain a situation in which you had a conflict and how you resolved it. What would you do differently? Why?What do you believe can be determined about an applicant at an interview?Define success.How well do you handle stress?Discuss a situation in which you showed leadership ability.Do you think one person can make the world a better place? Why or why not?How will you make the world a better place?Explain an ethical dilemma that you faced and how you dealt with it. Tips for a Winning Grad School Interview Experts and academic admissions officers offer these hints for having a positive grad school interview.   Practice your answers: Now that you know some of the questions to expect, think about how youd respond. Write down your thoughts to organize them, but dont memorize them or you might come across as stiff during the interview.Think of relevant personal stories: These stories demonstrate how your life experiences have led you to grad school.Dont forget about funding: Higher education is very expensive, and many graduate programs offer their students teaching assistantships or grants to help them defer costs.Interview your interviewers: You want to make sure youll be studying with faculty who share your academic goals and intellectual interests. Think of questions that youd like to ask about the culture of the program and how students and faculty interact.Be yourself: Youre committing yourself to a year or more of intense academic study, and grad school isnt cheap. If you cant honestly tell your interviewers why you want to be admitted to their program, that may be a sign that that prog ram wouldnt be a good fit. Sources 2017 CGS/GRE Survey of Graduate Enrollment and Degrees.Murray, Gregg R. 7 Key Questions to Ask During Your Grad School Interview. PsychologyToday.com. 18 Dec. 2014.Petersons blog staff. Graduate Admission: Tips for a Great Interview. Petersons.com. 29 Nov. 2017.Struefert, Billie. How to Ace Your Grad School Interview. USAToday.com. 20 Feb. 2015.

Using Home Design Software - A Review

Using Home Design Software - A Review Home Designer ® by Chief Architect is a line of software programs for non-professionals. Intended to help the Do-It-Yourselfer (DIYer) create workable home and garden plans, these applications cost less than professional-grade software. Not simplified or simple-minded,  Chief Architect products can teach you more about construction and design than a semester course at the local community college. And they are fun to use. Advertisements promise that this software will save you from napkin sketching, thanks to an integrated mobile Room Plannerâ„ ¢ app which lets you measure and plan rooms on the go and then import the file into Home Designer. You might love napkin sketching, but youll still want to test out the next step in home design. For the inexperienced, try out the middle-of-the line product, Home Designer Suite. You may hit some bumps along the way, but youre sure to find some happy surprises. Heres the scoop on the 2015 version. Using Home Designer Suite Every year is a new version, but most applications work the same way. Download files from homedesignersoftware.com or purchase the DVD. Installation is the straightforward 10-15 minute process. Then jump right in. Create New Plan makes you choose a house style before anything else. This gets you thinking about what look you want for your new construction or what style your built house might be. Of course, the problem with style is that very few house styles are pure Colonial or Country Cottage or Arts Crafts. Select one of the style choices, however, and you get a simple illustration along with written content that defines what they mean by the style. For example, Urban Chic/Contemporary is described as clean and spare. When you first begin, the software prompts you to make decisions - for example, choose a core catalog for your library, framing defaults, exterior siding. Construction pros understand the need to know wall height and thickness before building. However, if you are impatient, you might feel frustrated by the need to choose style details before getting started. The house style you have chosen loads an array of default style choices. Not to worry, however - these defaults can be changed at any time. Still, the creative side of you  may begin wishing for the napkin part of the process - a distraction-free work area to sketch out your inspirations. Building, Not Drawing The default work area in Home Designer looks like a piece of graph paper, although this Reference Grid can be turned off. The unsaved file is called Untitled 1: Floor Plan, so you may want to get into the habit of saving your electronic work often, just as you would in any software program. The cursor is at the crosshairs, beginning at the 0,0 point of an x-y axis. Its all movable, so the new user may reasonably decide to draw a floor plan with a drag-and-drop motion. But Home Designer in 2015 doesnt work like that. The user of Home Designer software does not really draw or sketch a design, but builds and constructs a home. If you begin with the Build drop-down menu, you will see Wall at the top of the list. Each wall section is considered an Object, so once each object is placed, you can select and move it around. The program functions like a builder - it progresses one wall at a time, one room at a time. An architect often thinks more abstractly and conceptually at first - a sketch on a napkin. In contrast, Home Designer functions more like a builder. Using this software, you may feel more like Bob the Builder than architect Frank Gehry. Results: The Wow Factor The very impressive 3D renderings will amaze you. The floor plan that you build can be viewed in multiple ways - overhead like a dollhouse, different camera views, and even a virtual walkthrough along a path you define. This DIY software takes away the mystique of any architect, designer, or construction professional who tries to wow the public with a virtual reality presentation. Anyone can do it; its baked into the software. If You Dont Read the Directions First Remember this, if youre not in the habit of reading instructions before you begin (you know who you are):   (1) Use Build then (2) Select objects to move and modify. In addition to this Build and Select method, Home Designer Suite has two more ways to get your project going: Tools Space PlanningCreate Room Boxes to rearrange, then select Build House from the drop-down menu and poof - the walls and rooms are all there.Go to the Home Designer Samples Gallery and download a zip file of sample plans and renderings. One look at the floor plans and 3D views, and youll say, Yeah, I want to do THAT! A nifty aspect of these sample plans is that they are not static or read only - you can take designs that someone else drew and modify them to your own specifications. Of course, you cant professionally USE them in any official way, because that would be stealing, but you can get a jump start on the learning curve. Product Documentation Tells All Every new edition of Home Designer Suite has its own version of a Users Manual and a Reference Manual. A very, very helpful feature of the Chief Architect website is that the company doesnt throw away much  - from the Product Documentation page, you can choose your version of Home Designer from a drop-down menu, and a PDF file is available for your product and the version (year) of the product. If you read the Reference Manual first, a first-time user may better undersand the focus on objects instead of concepts in the software environment created by Chief Architect. The environment is built on object-based design  - object-based design technology means you place and edit objects, rather than work with the many individual lines or surfaces used to represent them. The environment is 3-D drafting, a three dimensional coordinate system...using the X, Y, and Z axes. The current position of your mouse pointer displays in the Status Bar at the bottom of the program window. Architectural objects take up space in all three dimensions and their height, width and depth can be specified....In addition, the location of objects can be precisely defined using coordinates... How Easy is Home Designer Suite to Use? When the video says, Its that easy, well, its not that easy. For the uninitiated DIYer, a half-days worth of fiddling and training is recommended to become even semi-productive. Even after a full day of fiddling, front porch columns may go through the roof or stairways may end up as high as a rooftop. Although there may be easier ways to draw a floorplan, Home Designer software really gives a professional look to even the simplest of floorplans. While designing the floorplan, its very easy to switch to a different view, such as a 3D overhead called a dollhouse. When viewing the outside of your design, you can easily place your new home in a stock photograph setting or its even more fun to choose your vegetation from a list and do your own landscaping. The online Support Center and drop-down Help menu are phenomenal. Help documents are constantly being updated, including: Frequently Asked Questions and Knowledge Base, a database of FAQs and solutions to specific questionsHome Designer Getting Started Resources, which may include access to too much informationClassroom Training, Webinars, Online and Mobile Training VideosCustomer Service Telephone SupportHome Talk forum and discussion group specifically for Home Designer software users The newbie might want to start with a quick tutorial and then reference the online Users Manual and the Reference Manual. 5 Reasons to Use Home Designer Software It makes you think about design, how elements/objects fit together, and how standard sizes and shapes of appliances can dictate interior design.It may save you money when you use an architect that charges by the hour. If you can conceptualize your ideas using the language of the professional designer or architect, communication will be faster and your expectations can be better thought through.The many standard features will keep you busy for weeks. The uninitiated will not outgrow this software anytime soon.Not only does the software integrate with the Room Planner app, but users can import photos of their own homes for landscaping and remodeling projects.Great support. Affordable price. Other Considerations Once you get the knack of using the software, its just too easy to make complicated designs. Walls and juts are easy to add, but theres no on-screen calculator to show you the immediate construction costs of what you are doing. Beware of sticker shock! Three-dimensional renderings include a snazzy ability to record a virtual walk-through. However, you will not be able create the simple yet elegant line drawings found in the work of professional architects. For that type of elevation drawing, youd need to move up to the Chief Architect product line created for professionals at chiefarchitect.com. Too many options can be paralyzing. Take your time and build your knowledge. Green initiatives and Green Building Software Tips are available online for the Chief Architect professional software. It would be nice to see these tips directed to the everyday consumer, too. Chief Architect, Inc. offers two lines of software products: Home Designer for the Do-It-Yourselfer consumer and Chief Architect for the professional. Both product lines are by Chief Architect, and both are described as Home Design Software. Which program to purchase could be confusing, so check out both the Home Design Software products and the Chief Architect product comparison. Chief Architect has been making professional architectural software since the 1980s. The Home Designer line builds on years of experience with a complex interface. The heftiness of the manuals and the need for so much support suggests the possible need for a more intuitive user experience. Fortunately, the documentation is excellent. After a day of tinkering and discovering what is possible, anyones imagination should soar.  Home Designer can be challenging to master, but well worth the effort. Cost The Home Designer family includes multiple products that range in price from $79 to $495. Students and academic institutions can license the products when adopted as a teaching tool. Trial downloads are available, and Chief Architect backs all products with a 30-day money-back guarantee. If your home projects focus on remodeling or interior design, Home Designer Interiors might be a better purchase at $79. Internet access is required for installation, license authentication, deactivation, video, and library catalog access. Internet access for license validation is required once every 30 days; for Home Designer Pro, license validation is required once every 14 days. Sources Chief Architect Home Designer Suite 2015, User’s Guide, http://cloud.homedesignersoftware.com/1/pdf/documentation/home-designer-suite-2015-users-guide.pdfChief Architect Home Designer Suite 2015, Reference Manual, p. 21, http://cloud.homedesignersoftware.com/1/pdf/documentation/home-designer-suite-2015-reference-manual.pdfRendering examples by Jackie Craven Disclosure: A review copy was provided by the manufacturer. For more information, please see our Ethics Policy.

Patient engagement programs Assignment Example | Topics and Well Written Essays - 250 words

Patient engagement programs - Assignment Example The strategy design also focuses on forming a health information technology that will support the provision of quality health care for all the parties involved in the health care system including laboratory services. The strategy will also ensure that there is easy access to complete HIT that incorporates the long-term record of a patient electronically to EHR. The strategy designed will also be friendly with easy access to online materials. The need to engage patients is due to the existence of regulatory mandates that demand the need of engaging patients when designing strategies. The growing demand for the use of digital technology development and its innovation has also encouraged the need for patient engagement in the healthcare system. The existence of personal information technology has enabled people to be more responsible for their health and get support on healthy lifestyles. PHIT entails communications that are all about secure communication with the relevant health provid ers. Convenient self-service is another category of PHIT that entails being able to locate a facility and make appointments. PHIT also involves personal health information that ensures access to personal data. Financial and education support are also part of PHIT that enables the ability to pay bills and get support from the community respectively. There is also the general capabilities in PHIT that enable management of insurance and coverage and being able to manage profile and analyze data on health.

Lean Manufacturing Essay Example | Topics and Well Written Essays - 2500 words

Lean Manufacturing - Essay Example Current process The present procedure is one with an 8 hour shift for 20 days in a month, with both Fridays and Saturdays observed as off-days. The details of the 11 current operations being run can be seen in figure 1. Initially the present VSM or Value Stream Mapping has been developed. VSM is basically is a method to understand the dense relationship between each of the operations. It depicts time elapsed, non-conformance number, inventory and the flow of information between operations. The following advantages of VMS have been elaborated by Tapping, et al. (2002): a) Envision all of the flow of information and material used. b) Envision the relationship between operations and production control. c) Point out the waste sources in the system. d) Identify bottleneck operations. Afterwards statistical charts like bar chart, pie charts and waterfall charts are constructed. For this purpose, all the activities in the operation that that value or non-value added, must be highlighted. Va lue added activity is one which creates value, as customers perceive it. On the other hand, non-value activities are those, for which, the customer will not be liable to pay for. For this reason all non-value activities should be removed from the process immediately. In this scenario, cycle time is a value added activity whereas the set-up time and waiting time are tagged as non-valuable activities. Reason behind future state The immediate target of the future plan is to nullify all non-valuable activities and wastes. Waste is described as the process that does not help in cost reduction and also as a process that doesn’t add to the product value. In total, waste can be categorized in seven parts: 1. Waiting 2. Needless inventory 3. Flaws 4. Transportation 5. Overproduction 6. Incorrect processing 7. Needless motion Nevertheless, another waste which is also considered in this list as the eight waste is over-employment, which means employees, whose services are not fully utili zed. This disease can only be curbed by the input of the employees in the company with innovations and better working ideas. Three major motives are involved in the consideration of lean manufacturing in the very first place. First and foremost is the expanding of the market at a global stage. Then comes, the higher demands of the customer in relation to quality and a better cost. Lastly, the old school methods are no longer accepted, for e.g. once a month delivery of the products to the customer. Lean manufacturing is an outstanding approach to achieve better operations, quality and cost wise. It is a sluggish process but contributes heavily to lessening of wastes. Additionally, it is more prone to increasing the quality of the process. The major motives behind VMS are listed and elaborated as follows: 1. TAKT time and bottleneck station TAKT is the essential element that has to be considered in lean manufacturing to meet the requirements of the customer. According to Carreiera (20 05), TAKT is defined as â€Å"the frequency with which your customer consumes a unit of product†. In simple words, it can be established about TAKT time that, it is the time available for producing a product which is parallel to the needs of the customer. TAKT time can be calculated by the following formula: If the time of the process is less than the

Marketing Plan Coursework Example | Topics and Well Written Essays - 500 words

Marketing Plan - Coursework Example At the same time, one can enjoy the great taste of a carbonated drink with perfect nutritional intake. VegShot is being launched by Unilever. The name ‘Unilever’ is familiar to everyone. The name itself represents reliability and ensures quality. Unilever is a British-Dutch multi-national corporation, established in 1890s, which is operating in nearly 180 countries, possessing more than 400 brands. It has 167000 employees, as of 2010, belonging to 22 different nationalities. It is a global market leader in all Food categories including Savory, Spreads, Dressings, Tea and Ice Cream as well as in Mass Skin Care and Deodorants and has very strong positions in different Home and Personal Care categories. Its portfolio ranges from nutritionally balanced foods to indulgent ice creams, affordable soaps, luxurious shampoos and everyday household care products. The vision of Unilever is based upon the four pillars: To create a better future every day. To help people feel good, lo ok good and get more out of life with brands and services that are good for them and good for others. To inspire people to take small everyday actions that can add up to a big difference for the world.

An Introduction To DNA

An Introduction To DNA DNA (deoxyribonucleic acid) is the genetic material of eve living organisms including some viruses. It is a dimer consists of two strands that immerse upon each other and appear as a double helix that are linked together covalently with each other. Each strand is made up of similar repeating units called nucleotides. Each nucleotide composed of three different moieties,a 2-deoxyribose sugar,a phosphate group and a nitrogenous base. 1.1.1 2-Deoxyribose sugar The 2-deoxyribose sugar, a major structural component of DNA is a cyclic molecule .The sugars are joined together by phosphate groups that form phosphodiester bonds between third and fifth carbon atoms of adjacent sugar rings.The 5 carbon of deoxyribose sugar is attached to the 3 carbon of the next, and make a network of 3 carbon and 5 carbon.5end of a DNA molecule is characterized by a free phosphate (P) group and the 3 end is characterized by a free hydroxyl (OH) group. It lacks an hydroxyl group at the 2 position as in a ribose therefore a sugar moiety is a 2-deoxyribose. Two free hydroxyl groups are also located on the 5 carbon and 3-carbon of 2-deoxyribose sugar.These hydroxyl groups give a DNA oligomer its designation of 5 and the 3 end(usually accent as three prime end and five prime end). 1.1.2 Sugar-Phosphate backbone The 2-deoxyribose sugar and a phosphate group forms the backbone in the DNA which are highly polar and defines directionality of the molecule. The polar hydrophilic back- bone is surrounded by a core of hydrophobic bases and is important for the stability and structure of DNA. The phosphate groups have a negative charge that gives a concentra- tion of negative charge on the backbone of DNA and also makes DNA,a negatively charge 5 1 Fundamentals molecule. The charge is also neutralised by DNA-binding proteins that contain the pos- itively charged amino acids lysine and arginine, which are attracted to the negatively charged phosphate backbone. See Fig. 1.1. Figure 1.1: DNA backbone 1.1.3 Nucleic acid bases DNA contain four different nitrogenous bases that make monomer of one nucleotide different from other. These bases are adenine (A), thymine (T), cytosine (C), and gua- nine(G). The bases come in two categories pyrimidines and purines. Larger nucleic acids adenine and guanine are members of a class of doubly ringed structures called purines while the smaller nucleic acids cytosine and thymine are members of a class of singly- ringed chemical structures called pyrimidines .A six-membered ring with two-nitrogen molecule formed a pyrimidine structure whereas purine is produced by a nine-membered, ring with four- nitrogen molecule. Each unit of the ring constructing the base is numbered to for specific identification. They are arranged in a particular order along the backbone of DNA to make a long chain of varying sequence that contains the code for proteins.The sequence specifies the exact genetic instructions required to create a particular organism with its own unique traits. 6 1 Fundamentals 1.1.4 Base Pairing in DNA The nitrogenous bases are responsible to form double-strand of DNA in consequence of weak hydrogen bonds and have specific shapes and hydrogen bond properties. The three hydrogen bonds form between guanine and cytosine and then denoted as G.C or C.G,depending on which is associated with the first strand. Similarly adenine and thymine also bond exclusively by pairing of two hydrogen bonds and then denoted as A.T or T.A. This coupling up of nitrogen bases termed as complementarity.,A hydrogen bond donor need an equivalent hydrogen bond acceptor to form a hydrogen bond in the base across from it. Purines are only complementary with pyrimidines because molecules in pyrimidine-pyrimidine pairings are very far from each other that doesnt makes the hydrogen bonding to be established. Purine-purine pairing are energetically unfavourable because the molecules are too close and create an electrostatic repulsion. The only possible pairings are GT and AC. Primary and secondary amine groups or hy droxyl groups are common hydrogen bond donar while carbonyl and tertiary amines are common hydrogen bond acceptor groups. There are two hydrogen bonds between an A:T base pair. One hydrogen bond lie between the 6 primary amine of adenine and the 4 carbonyl of thymine. The other hydrogen bond form between the 1 tertiary amine of adenine and the 2 secondary amine of thymine. On the other hand,G:C base pair has three hydrogen bonds. One hydrogen bond lie between guanine with its 6 hydrogen bond accepting carbonyl and cytosine having 4 hydrogen bond accepting primary amine. The second hydrogen bond also formed between guanine on 1 secondary amine and cytosine 3 tertiary amine and the third formed between the 2 primary amine on guanine and the 2 carbonyl on cytosine. 1.1.5 Directionality The directionality of DNA is vitally important to many cellular processes. since,double helices are necessarily directional(a strand running 5 to 3 pairs with strand running 3 to 5 )and processes such as DNA replication occur in only one direction. The two DNA strands in a duplex are anti parallel and form a chemically stable structure. That is, one strand running from the 5-phosphate to 3-OH is paired with the other strand arranged with its 3-OH opposite the 5-phosphate of the first strand, and its 5-phosphate opposite the 3- OH of the first strand. 7 1 Fundamentals 1.1.6 3 end and 5 en DNA strand is inherently directional.The 3 prime end has a free hydroxyl (or phos- phate) on a 3 carbon and is called as the tail end. New nucleic acid molecules are formed by one end of 3-hydroxyl as it is ligated to the other end of 5-phosphate of a different nucleotide that make it possible to form strands of connected nucleotides.Molecular biologists can use nucleotides that has a deficiency of 3-hydroxyl(dideoxyribonucleotides) to stop DNA replication .The 5 prime end has a free hydroxyl (or phosphate) on a 5 carbon in the sugar-ring and this end is called as the tail end . If a phosphate group bind with the 5 end, ligation of two nucleotides can form, with a phosphodiester bond from the 5-phosphate group to the 3-hydroxyl end of other nucleotide. ligation can also stop if the above process is eliminated. Molecular biologists have an advantage of the above phenomenon to stop ligation of any unnecessary nucleic acid by removing the 5-phosphate with a phosphatase. 1.2 DNA-Ligand Binding The structure of DNA represents a variety of sites where ligands may interact and bind with DNA.The binding interaction between a drug and DNA often leads to a signi_- cant modi_cation of the structure of the DNA and may have an important inuence on their physiological functions associated with several biological e_ects including antivi- ral,antibacterial,antipotozoal and antitumor. Modes of Binding Because of the complex double-helical structure of DNA,drug molecule interact with DNA in a number of modes. A number of forces of varying strength involved in each interaction. Electrostatic forces with the phosphate backbone,sequence sensitive van der Waals interaction and hydrogen bonding interactions that occur between polar atom of bases and hydrogen molecules are incorporated singly or in combination.To understand the mechanism of interaction of each mode,it is best to discuss di_erent binding modes that can act on DNA. (a) External Binding (b) Intercalators (c) Groove binding (i) Major groove binders (ii)Minor groove binders External Binding This type of binding results due to electrostatic forces applied to the negatively charge phosphodiester group along the backbone of DNA for cationic molecule.Ligand charge, hydrophobicity and size a_ect on electrostatic interactions.External binding may also be due to either covalent or non-covalent interactions.This mode of binding is characteristics for major groocould potentially be sampled during simulations where the charge and shape of helical molecules are both changed. Intercalators An important class of molecules that binds to DNA are intercalators,which have been extensively used as a anti-cancer drug.Intercalation occurs due to immersion of a at aromatic drug molecule between nucleic bases contributes to unwind DNA helix(67).The interaction between a positively charged intercalator and a negatively charged DNA can be quite strong and form complex through electrostatic forces.Energy consumed to unstacked the nucleic acid bases which forms a gap between neighbouring base pairs into which the intercalator can _t easily.Because of small binding site,they have a little sequence selectivity and many known intercalators shows limited selectivity for GC base pairs such as ethidium bromide which has a high a_nity towards GC site.Several other drugs such as propidium,proavin, anti-tumor drugs adriamycin and actinomycin D intercalate with DNA. Groove Binders Smaller ligands preferentially binds to minor groove region whereas proteins and other large molecules speci_cally _ts into the major groove region of DNA. They have crescent -shaped conformation due to presence of two or more than two aromatic rings that gives a conformational exibility to the molecule and makes it perfect to _t in the groove. They also possess some functional group that forms hydrogen bonds at lower most part of DNA bases.They perfectly accommodate in the AT rich regions but some known groove binders show little preference towards GC site. Major Groove binders Presence of number of hydrogen bonds on the DNA major groove enhance its recognition potential. Major groove speci_c compounds are alkylating and methylating agents and and N 7 position of guanine in the major groove take part in interaction.one of the most common example is Cis platin which is a well known anti cancer drug. Minor Groove binders The most widely studied DNA interacting agents are minor groove binders that occurs naturally and also synthesize according to their sequence speci_c properties as they have pronounced binding a_nity towards AT rich groove.AT binding site is more thinner and deeper than GC so that all heteroaromatic rings such as furan,pyrole,benzene and Imidazole of minor groove binders twisted and _t better into AT site by applying van der waals force.Hydrogen bonds of bound molecule attached to the AT base pairs to the C-2 carbonyl oxygen of thymine or N-3 nitrogen of adenine.GC base pairs also contain same functional groups but a steric block form by amino group of guanine in GC locations which causes hinderence to the formation of hydrogen bond on guanine at N-3 position and on cytosine at O-2 cabonyl position,prohibiting vad derWaal forces and inhibit penetration of small molecules at GC sites of minor groove.AT site selectivity for positively charged minor groove binders also enhanced due to high negative electrostatic potential as compared to GC site. A number of experimental studies shows that minor groove of B type of DNA duplexes more suitable for binding of small molecules most often with Dickerson-Drew sequence d(CGCGAATTCGCG) and also similar such as d(CGCAAATTTGCG). 1.3.1 Berenil X-ray crystallography proof complex formation of berenil with dodecanucleotides,i.e. d(CGCGAATTCGCG) and d(CGCAAATTTGCG)which in turn shows its preference of binding with AT rich site of DNA minor groove and reside between three (AAT) or four(AATT) base pairs. A number of research on berenil also con_rm its weak interac- tion and intercalating behavior.Hydrogen bonds are also formed between the amidinium groups and adenine N-3 or thymine O2 atoms on reverse strands of a double helical DNA oligonucleotide.Berenil is a curve shape drug which match the helical structure of DNA minor groove. 1.3.2 Pentamidine One of the most clinically important drug,pentamidine is a synthetic antimicrobial com- pound also known aspentamidine (1,5-bis(4-amidinophenoxy)pentane,among all the mi- nor groove binders.It has been use as a secondary drug for treating aids related P.carinii pneumonia.Foot printing and X-ray crystallography shows its pronounced attachment to DNA sites which has minimum four to _ve successive AT base pairs with the charged amidinium group shows hydrogen bonding to O2 of thymine or N3 of adenine on oppo- site DNA strands. It contains two phenyl rings that are twisted after binding with the minor groove by 35ÂÂ ° with respect to each other by van der Waals forces. 1.3.3 DAPI DAPI also called 4,6-diamidino-2-phenylindole(DAPI) is a synthetic,unfused aromatic compound is widely used in molecular biology as a uorochrome on binding upon AT site of minor groove binder as well as an intercalating drug.upon binding to GC rich sequence without showing any property of uorescence.X-ray structure of DAPI with d(CGCGAATTCGCG)exhibited that the drug span three base pairs and also give a clear picture of parallel attachment of phenyl and indole rings to the minor groove walls of DNA. |||||||| 1.4 UV-Visible Spectroscopy Spectroscopy is a valuable tool in the study of intermolecular interactions. It is a well developed routine technique and plays an important role in analytical chemistry as well as it has widespread application in physics and life sciences. It deals with the mea- surement of the absorption of radiations in the ultraviolet and visible region of spec- trum.Spectroscopic techniques form the largest and the most important single group of techniques used in analytical chemistry,and provide a wide range of quantitative and qualitative information. All spectroscopic techniques depend on the emission or ab- sorption of electromagnetic radiations and used to determine the electronic structure of atoms and molecules. In order to understand these techniques,it is necessary to have some knowledge about properties of electromagnetic radiations and the nature of atomic and molecular energy. The ultraviolet region extends from 10 to 400nm.It is subdivided into near ultraviolet region (200 to 400nm) and the far or vacuum ultraviolet region(10 to 200 nm).The visible region extends from 400 to 800 nm. 1.4.1 Electromagnetic radiations Electromagnetic radiations are produced by the oscillation of electric charge and mag- netic _eld residing on the atom and has its origins in atomic and molecular processes. It vibrates perpendicular to the direction of propagation with a wave motion and can travel in space and does not need a medium like air or water to travel through. There are various forms of electromagnetic radiations e.g. visible,ultraviolet,infra-red, X-rays,microwaves and cosmic rays. They are characterised by frequencies,wavelength or wave numbers. The most familiar form of electromagnetic radiations is visible light which forms only a small portion of full electromagnetic spectrum. Electromagnetic spectrum A plot which shows a number of absorption bands with respect to energy versus wave- length has some properties yield various information and is broken into several regions called as Electromagnetic Spectrum.Di_erent regions of the electromagnetic spectrum provide di_erent kinds of information as a result of interactions. Electromagnetic spec- trum covers a very wide range of electromagnetic radiation that starts from gamma rays and ends on to radio waves. The boundaries between the regions are approximate and the molecular process associated with each region are quite di_erent.The regions in increasing order of frequency are 1/ Radio frequency region ;Nuclear magnetic resonance and electron spin resonance spectroscopy.The energy changes with change in direction of spin of a nucleus and elec- tron. 2/ Micro wave region:Rotational spectroscopy .Change in energy arise from transi- tions to higher energy associated with change in the rotational quantum number of the molecule. 3/Infra-red region:Vibrational spectroscopy The energy changes associated with transitions between vibrational levels of molecules. 4/Vis- ible and Ultraviolet region:Electronic spectroscopy The energy changes accom- pained with valence electrons of molecules. 5/X-ray region: inner electrons of an atom or a molecule invole in order to change energy of molecule. 6/ X-ray region: nuclear excitations necessary for an enegy change. 1.4.2 Law of molecular Absorption:Beer-Lambert law All spectrophotometric methods that measure concentration in terms of absorbance,including detection of proteins and nucleic acids,determine molar absorptivity of metal com- plex,various enzyme essay,describe attenuation of solar or stellar radiation and di_er- ent metabolites based upon two basic rules,which combinely spoken as Beer-Lambert law.This law was basically originate by a French mathematician Lambert,which states that the function of light absorbed by a transparent medium s independent of the inci- dent light assing through it.This shows that logarithm of the decrease in light intensity along the light path with respect to thickness of medium which can be written as follow log10(I0/I) = kl where IÂÂ ° is incident light intensity,I is light path length,k is a medium constant which is further interpret by a Beer,a German Physicist in the same year states that the amountof light absorbed is proportional to the number of molecules of the chromophore through which the light passes.One can also says that constant K is directly proportional to the chromophore concentration i.e. K=eC,e is the molar absorptivity of chromophore and is equal to absorption of 1M of solution at a path length of 1 cm and their unit is M-1cm-1.Now,combinely Lambert-Beer law presented as A = lC, whereby,the term log10(I0/I) is re_ered as absorbance(A),l is the thickness of solution and E is the molar absorption coe_cient. 1.4.3 Electonic transitions in Nucleic Acids Absorption or emission of radiations in nucleic acid causes di_erent types of transitions in UV-visible spectral regions and appear from n-pi* and pi -pi* transitions of purine and pyramidine bases. -* transition Large amount of energy required for the shifting of an electron from a bonding molec- ular orbital to a * antibonding molecular orbital in the UV region.Unsaturated hydro- carbons shows this type of transition and being transprent in the near UV such as methane,heptane and cyclohexane that shows maximum absorbance below 200 nm due to the fact that absorbance is equal to 1 for a thickness of 1 cm below 200nm. Similarly, water in the near UV(A=0.01 for 1cm ,at lambda =190nm)is transparent due to the presence of -* and n-* transitions. n- *transition This type of transition usually occur in compounds having lone pair of electrons and required energy lower than -* transition for the promotion of an n electron from an atom to an * molecular orbital.Moderate wavelength range for this transition is 150 to 250 nm as 180nm for alcohols,near 190nm for ethers or halogen derivatives and in the region of 220nm for amines. *transition Most of the organic compounds have a conjugate system and shows -* transitions with an intense strong absorption band occuring anywhere in the near UV region which depends upon the presence of heteroatoms substituents.These compounds also shows a slightly blue and red shift with respect to its polarity. n- *transition These bands are called forbidden bands having a low molar absorptivity less than 100 and originate from promotion of electron from a non bonding molecular orbital to an anti-bonding *orbital.This transition is more pronounced in molecules having a hetero atom with a lone pair of electron i.e.carbonyl which requires low energy and occur in the regions from 270 to 300 nm. d-d transition electrons placed in incompletely _lled d orbitals of most of the inorganic salts are re- sponsible for transitions of weak absorption and also color and located in the visible region..That is why the solutions of metallic salts of titanium or copper are blue,while potassium permeganate yeilds violet solutions, and so on. 1.4.4 Chemical shift Bathochromic shift change in max to longer wavelength(lower frequency)also change absorption,reectance transmittance or emission spectrum of a molecule mostly due to substitution or solvent e_ect i.e change in polarity of solvent called as bathochromic shift or red shift.Solvent e_ect is weak in less polar compounds as compared to polar one which can stabilise excited form,favours transition and causes a change in wavelength towards longer side. Hypsochromic shift The opposite e_ect of bathochromic shift also called as blue shift as max shift towards the blue end of spectrum.Unbonded electron pair lowers the energy of the n-orbital and increased solvation causes hysochromic shift.Mostly polar solvents such as water and alcohol have pronounce e_ect of hypsochromism due to broad hydrogen bonding between protons and the non-bonded electron pair during solvation. Hypochromic shift reduction in the intensity of uv light without any change in wavelength called as hypochormic e_ect which caused by the entry of an auxochrome which distrots the chromophore.For example ,biphenyl shows lAMDAmax 252nm,Emax19,000,whereas 2,2-dimethylbiphenyl shows Lambda max 270nm,Emax 800. Hyperchromic shift This e_ect leads to an increase in absorption of UV light at same wavelength due to appearance of an au that causes hyperchromic shift.For example,benzene shows B-band at 256nm,Emax 200,whereas aniline shows B-band AT 280nm,Emax 1430.The increase of 1230 in the value Emax of aniline compared to that of benzene is due to the hyperchromic e_ect of the auxochrome NH2. 1.4.5 Chromophore groups Organic compound mostly containing double bond is responsible to produce color and absorption of ultraviolet or visible radiations as single bond is not enough to do that but if many are present in conjugations,sharp color can produce. A single functional group or a collection of functional groups also capable for absorption and they also act as a chromophore. A complex molecule can contain more than one chromophore so the e_ect of conjugation on the chromophore is to shift the maximum absorption to a longer wavelength .i.e. a bathochromic shift or red shift appear with an increase in absorption intensity and the spectrum is strongly upset with respect to the superimposing e_ects of random chromophores. The more the number of carbon atoms on which the conjugated system is spreaded,the more the decrement in the di_erence between energy levels.and accounts large bathchromic e_ect. A very simple spectrum of a compound having one main peak absorbing below 300nm possibly contains a very simple conjugated system Instrumentation in UV-Visible Spectrophotometer UV-Visible spectrophotometer is a very simple to operate and able to perform quick qualitative as well as quantitative analysis.It is usuallay designed around _ve funda- mentals parts i.e. a radiation source,a monochromater(wavelength selector),a samplecell(cuvette),detector and a signal processor (readout device) for measuring the absorp- tion of uv or visible radiations.These components are typically integrated in a unique frame work to make spectrometers for chemical analysis.Two types of UV-Visible spec- trophotometers are generally in use:a _xed spectrophotometer with a single beam and a scanning spectrophotometer with double beams.Single beam spectrophotometers are highly sensitive devices and obtaining a spectrum requires measuring the transmittance of the sample and the blank at each wavelength separately.In the double beam spec- trophotometer,the light split into two parallel beams,each of which passes through a cell;one cell contains the sample dissolved in a solvent and the other cell contains the solvent alone.The detector measures the intensity of light transmitted through the sam- ple cell. Light source The intensity of radiation coming from the light source varies over the entire UV-Vis range.More than one type of source can be used in UV-Vis spectrophotmeter which au- tomatically swap lamps when scanning between the UV and visible range .A deutrium lamp is used for the wavelengths in the UV range,a tungsten lamp is used for the wave- lengths in the visible range and alternatively for the entire UV-Visible region,a xenon lamp can be used. Monochromator Its role is to spread the beam of light into its component wavelengths and a system of slits focuses the desired wavelength on the sample cell.The most widely used dispersing device is a prism or a grating made p of quartz because quartz is transparent throughout the UV range. Detector The detector converts the intensity of light reaching it to an electrical signal.It is by nature a single channel device.Two types of detector are used,either a photomultiplier tube or a semiconductor.For both of which the sensitivity depends upon the wavelength. QSAR and Drug design Quantitative structure-activity relationship (QSAR) (sometimes QSPR: quantitative structure-property relationship) is the process by which chemical structure is quanti- tatively correlated with a well de_ned process, such as biological activity or chemical reactivity. For example, biological activity can be expressed quantitatively as in the concentra- tion of a substance required to give a certain biological response. Additionally, when physicochemical properties or structures are expressed by numbers, one can form a math- ematical relationship, or quantitative structure-activity relationship, between the two. The mathematical expression can then be used to predict the biological response of other chemical structures. QSARs most general mathematical form is: * Activity = f(physiochemical properties and/or structural properties) Quantitative structure-activity relationships (QSAR) represent an attempt to corre- late structural or property descriptors of compounds with activities. These physico- chemical descriptors, which include parameters to account for hydrophobicity, topology, electronic properties, and steric e_ects, are determined empirically or, more recently, by computational methods. Activities used in QSAR include chemical measurements and biological assays. QSAR currently are being applied in many disciplines, with many pertaining to drug design and environmental risk assessment. Chromophore Organic compound mostly containing double bond is responsible to produce color and absorption of ultraviolet or visible radiations as single bond is not enough to do that but if many are present in conjugations,sharp color can produce. A single functional group or a collection of functional groups also capable for absorption and they also act as a chromophore. A complex molecule can contain more than one chromophore so the effect of conjugation on the chromophore is to shift the maximum absorption to a longer wavelength .i.e. a bathochromic shift or red shift appear with an increase in absorption intensity and the spectrum is strongly upset with respect to the superimposing effects of random chromophores. The more the number of carbon atoms on which the conjugated system is spreaded,the more the decrement in the difference between energy levels.and accounts large bathchromic effect. A very simple spectrum of a compound having one main peak absorbing below 300nm possibly contains a ve ry simple conjugated system such as diene or an enone whereas, if the spectrum is much mixed and also allocated in a visible region,then the molecule must contain chromophore having large red shift such as polyene ,polycyclic aromatic system etc. Solvent Effect Selection of solvent used in UV-visible spectroscopy is very important. The prime requirement for a solvent is that it should be transparent to radiation over full UV range and also not absorb UV radiations in the region of substance whose spectrum is actually analysed .Most of the organic solvents successfully meet that criteria and solvents without having any conjugtion are very convenient for this purpose.Among the solvents ,the water ,95% ethanol and hexane are most commonly used and are transparent in the full uv spectrum. Another valuable requirement for selecting a solvent is that it gives a nice spectrum of a set a absorption bands because polar solvent form hydrogen bonds with solute and the fine spectrum of the complex may vanish but this is not the case for non polar solvents where a fine spectrum often easily appears because of the absence of hydrogen bonding.Polar solvents also shows bathochromic effect which causes a decrease in electronic state. Asecond criteria for agood solvent is its effect on the fine strusture of an absorption band.Ano polar solvent doesnot hydrogen bond with the solute,and the spectrum of the solute closely approximate s the spectrum that would be produced in the gaseous state ,in which fine structure is often observed.In a polar solvent the hydrogen bonding forms a solute solvent comlex and the fine structure may disappear. Athird criteria for a good solvent is its ability to influence th